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KMID : 0359819940230040402
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Journal of Korean Neurosurgical Society
1994 Volume.23 No. 4 p.402 ~ p.407
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Immunohistochemical Detection of p53 and c-fos in Brain Gliomas
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손은익
이장철/김동원/임만빈/김인홍/이상숙
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Abstract
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The epidemiology of cancer has long been suggested that cancer is a multistep disease. We suspect some of these steps might be related with activation of oncogenes and loss of tumor suppressor genes in primary brain tumors. Moreover, recent
reports
suggest that astrocytomas have shown alterations in chromosome 17p, and this chromosomal location that encodes the p53 protein, as well as c-fos gene may take an important role in the carcinogenesis of human primary brain tumors.
Expression of p53 protein was detected in 12 of 17 cases(70.6%) of glioblastoma multiforme, 4 of 6 cases(66.6%) of anaplastic astrocytoma with positive nuclear p53 staining. All low grade astrocytomas and normal brain tissue failed to express
p53.
Correlation of p53 protein levels with mRNA alterations or genomic DNA alterations may help to guide future therapy or diagnosis of brain tumors. On the other hand, the level of c-fos oncoprotein expression may be correlated with the degree of
cell
differentiation and proliferation. The presence of these expression in low-grade astrocytoma suggest that activation of the c-fos gene is an early step in tumor development.
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KEYWORD
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